Yarra Biosystems

Tumor biology is shaped by interactions that conventional measurements cannot fully capture.

Yarra Biosystems is developing a new way to translate that complexity into more useful biological information for drug discovery and development.

Early-stage Spatial oncology, beyond static

Figure — representative tissue image

01 — Mission

A category that does not exist yet.

Spatial technologies have transformed how well tissue can be characterized. What they capture is still only part of the biology present in a sample. Yarra Biosystems is developing the means to reach the rest.

That work is underway with academic and translational research collaborators.

Tissue, illustrative
Cellular organization, illustrative
02 — Applications Read the applications
01

Target & Mechanism Discovery

Identify previously inaccessible tissue-level biology associated with disease mechanisms and therapeutic response.

02

Biomarker Development

Discover and validate biomarkers linked to disease biology and therapeutic response.

03

Therapeutic Development

Evaluate how emerging therapeutics affect complex tissue biology across oncology models.

04

Translational Intelligence

Turn complex spatial and biological data into interpretable insights for translational research and drug development.

03 — Momentum

Yarra Biosystems has come through university venture and commercialization programs, expanded its academic and technical network, and is pursuing non-dilutive funding.

Memberships & Programs

Yarra Biosystems participates in leading innovation and life-science ecosystems.

Also a member of AWS Activate

Collaboration

Now inviting early evaluation partners.

We are opening the platform to biopharma and translational science teams for target validation, run alongside the orthogonal assays they already use. Investors, strategic partners, academic collaborators and prospective advisors are also welcome.

Get in touch
Applications

Designed for translational oncology R&D.

A tissue-based research platform for target discovery, biomarker development, and therapeutic evaluation in oncology.

01

Target & Mechanism Discovery

Identify previously inaccessible tissue-level biology associated with disease mechanisms and therapeutic response.

02

Biomarker Development

Discover and validate biomarkers linked to disease biology and therapeutic response.

03

Therapeutic Development

Evaluate how emerging therapeutics affect complex tissue biology across oncology models.

04

Translational Intelligence

Turn complex spatial and biological data into interpretable insights for translational research and drug development.

From tissue to translational insight

One research platform connecting tissue biology across target discovery, biomarker research, therapeutic development, and translational analysis.

Built to investigate biological information that current spatial and molecular approaches do not fully capture.

For a fuller picture, start a conversation.

Contact us
Science

A More Complete Picture of Tissue Biology

Protein expression reveals important aspects of tumor biology. But tumor biology is shaped by more than expression alone.

The science

Tumor biology is dynamic, interconnected, and highly context dependent.

Protein expression provides one important view of that biology, but the meaning of those signals can change depending on the biological environment in which they occur.

What we connect

Different dimensions of the same tissue biology.

01

Protein Expression

Protein levels and localization reveal important pathways and cellular processes involved in disease and therapeutic response.

02

Tissue Context

Where cells are located, which cells surround them, and how tissue is organized influence how that biology is expressed.

03

Biological Information

Tumor tissue contains biological information that is not fully represented by expression or spatial organization alone.

How we work

More from the same tissue.

Static Measurements

Static measurements provide a valuable snapshot of tissue biology, but they capture only one moment in a more complex biological process.

One slice is not the sample

A single section samples a fraction of the material in front of you. We extend sampling well beyond that plane.

The signals that get lost first

Rare cells and low-abundance proteins disappear before anything else. We make them visible.

The opportunity

Tissue contains more biological information than expression alone can show.

Protein expression, spatial organization, and tissue architecture each reveal part of the biology. Together, they provide important context for understanding the complexity of tumor tissue.

About

Where pathology meets engineering.

Yarra Biosystems is an early-stage life sciences technology company focused on integrated tissue analysis in oncology.

Savanh Chantha-Phavong, Ph.D.

Founder, CEO & CSO

Translational Histopathology, Spatial Biology, Digital Pathology, Multiplex Imaging, Tumor Microenvironment

Corey Neu, Ph.D.

Cofounder, Scientific Development

Mechanical and Biomedical Engineering, Cellular Imaging and Mechanobiology

Donnelly Family Endowed Professor, Biomedical Engineering

University of Colorado Boulder

Why Yarra Biosystems?

Named for where the journey began.

Yarra Biosystems takes its name from the Yarra River, or Birrarung, in Melbourne, Australia, where our cofounder Savanh Chantha-Phavong’s scientific journey began.

The Birrarung rises in the forested ranges of Victoria, gathering tributaries as it moves through different landscapes and communities before winding through Melbourne and opening into Port Phillip Bay. For the Wurundjeri Woi-wurrung people, the Traditional Owners of much of the land along the Birrarung, the river has long held cultural, ecological and community significance.

That idea of convergence reflects how Yarra Biosystems is being built.

Biology does not happen in isolation. Protein expression is one part of a broader biological context shaped by how cells and tissues are organized. Tumor, immune and stromal cells continuously influence one another, while proteins translate those interactions into the biological states we observe.

Understanding disease therefore requires more than looking at any one cell, marker or technology alone.

Yarra Biosystems brings together pathology, oncology, spatial biology, engineering, biomaterials and molecular technologies. Just as importantly, we bring together people, ideas, expertise and different ways of thinking.

Like tributaries joining a river, each contributes something different. Together, they create the opportunity to see biology more completely.

Our ambition is to use that convergence to unlock far more information and insight from tissue than has previously been possible, helping uncover new therapeutic targets, clinically meaningful biomarkers, and ultimately better therapies.

Our work now spans continents. Our cofounder is based in the San Francisco Bay Area, while our name remains rooted in Melbourne and the place where it began.

The Birrarung begins in the ranges, gathers strength from what joins it along the way, crosses boundaries and opens toward a much wider horizon.

That is what Yarra Biosystems represents: bringing together the right people, ideas, expertise and technologies to build something capable of revealing far more from tissue than any one approach could alone.

News

News and announcements.

Yarra Biosystems joins the NVIDIA Inception Program.

Yarra Biosystems has been accepted into NVIDIA Inception, a program that supports startups building with AI and accelerated computing.

To hear about it first, get in touch.

Contact us
Contact

Start a Conversation.

We welcome conversations with biopharma and translational research teams, early adopters, collaborators, investors, strategic partners, and prospective advisors.

If you are interested in evaluating the platform, exploring a collaboration, or learning more about Yarra Biosystems, we would be glad to hear from you.

Yarra Biosystems hello@yarrabio.com
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